J Marc Simard Selected Research

Glyburide (Glibenclamide)

1/2022	Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide.
6/2021	An update on the pharmacological management and prevention of cerebral edema: current therapeutic strategies.
1/2021	SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.
1/2020	Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence.
1/2020	Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury.
1/2020	SUR1-TRPM4 channels, not KATP, mediate brain swelling following cerebral ischemia.
12/2019	BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema.
11/2019	Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction.
10/2019	SCING-Spinal Cord Injury Neuroprotection with Glyburide: a pilot, open-label, multicentre, prospective evaluation of oral glyburide in patients with acute traumatic spinal cord injury in the USA.
1/2019	Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.

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J Marc Simard Research Topics

Disease

34	Brain Edema (Cerebral Edema) 01/2022 - 04/2006
33	Edema (Dropsy) 01/2022 - 01/2004
27	Stroke (Strokes) 10/2022 - 01/2003
20	Traumatic Brain Injuries (Traumatic Brain Injury) 06/2021 - 02/2008
19	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 12/2021 - 02/2009
18	Hemorrhage 01/2022 - 12/2008
17	Ischemia 01/2020 - 01/2004
16	Infarction (Infarctions) 01/2022 - 04/2006
15	Ischemic Stroke 10/2019 - 12/2002
13	Spinal Cord Injuries (Spinal Cord Injury) 06/2022 - 08/2007
12	Wounds and Injuries (Trauma) 01/2021 - 02/2008
12	Brain Ischemia (Cerebral Ischemia) 01/2020 - 01/2011
9	Brain Injuries (Brain Injury) 07/2022 - 06/2003
9	Neuroinflammatory Diseases 01/2021 - 07/2012
8	Necrosis 02/2022 - 08/2007
8	Hypoxia (Hypoxemia) 05/2015 - 01/2004
7	Inflammation (Inflammations) 01/2022 - 02/2009
6	Hypertension (High Blood Pressure) 12/2013 - 01/2003
5	Pain (Aches) 07/2022 - 01/2019
5	Spinal Injuries (Spinal Injury) 01/2021 - 01/2017
5	Brain Contusion 01/2020 - 12/2009
5	Contusions 01/2020 - 02/2012
4	Hypothermia 06/2022 - 11/2015
4	Cerebral Infarction 01/2021 - 01/2011
4	Neoplasms (Cancer) 01/2018 - 11/2005
4	Brain Neoplasms (Brain Tumor) 12/2017 - 10/2013
4	Brain Diseases (Brain Disorder) 05/2015 - 12/2011
3	Aneurysm (Aneurysms) 10/2019 - 12/2013
3	Heart Arrest (Cardiac Arrest) 01/2018 - 10/2011
3	Type 2 Diabetes Mellitus (MODY) 01/2018 - 10/2013
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 08/2015 - 02/2009
2	Headache (Headaches) 07/2022 - 12/2021
2	COVID-19 02/2022 - 01/2022
2	Cytokine Release Syndrome 02/2022 - 01/2022
2	Acute Pain 12/2021 - 11/2021
2	Neurocognitive Disorders (Clerambault Syndrome) 10/2021 - 01/2021
2	Neuralgia (Stump Neuralgia) 01/2021 - 01/2019
2	Thrombocytopenia (Thrombopenia) 01/2021 - 12/2013
2	Venous Thrombosis (Deep-Vein Thrombosis) 01/2021 - 12/2013
2	Gliosis 01/2021 - 09/2017
2	Hydrocephalus (Hydrocephaly) 01/2020 - 08/2017
2	Intracranial Hypertension 01/2019 - 10/2015
2	Glioma (Gliomas) 01/2018 - 01/2017
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 09/2017 - 11/2015
2	Hemorrhagic Stroke 03/2015 - 10/2013
2	Craniocerebral Trauma (Head Injury) 12/2009 - 05/2009

Drug/Important Bio-Agent (IBA)

46	Glyburide (Glibenclamide)FDA LinkGeneric 01/2022 - 04/2006
26	Sulfonylurea ReceptorsIBA 12/2020 - 04/2006
21	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2004
17	Proteins (Proteins, Gene)FDA Link 02/2022 - 01/2006
9	Pharmaceutical PreparationsIBA 10/2022 - 12/2013
8	Heparin (Liquaemin)FDA LinkGeneric 01/2021 - 12/2010
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2022 - 02/2009
6	CationsIBA 08/2015 - 01/2004
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2006
5	Ion Channels (Ion Channel)IBA 01/2020 - 08/2009
4	CytokinesIBA 02/2022 - 01/2020
4	Explosive Agents (Explosives)IBA 08/2019 - 10/2011
4	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2018 - 09/2012
4	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018 - 09/2012
4	Immunoglobulin G (IgG)IBA 08/2015 - 02/2009
3	Opioid Analgesics (Opioids)IBA 07/2022 - 11/2021
3	Interleukin-6 (Interleukin 6)IBA 02/2022 - 01/2021
3	Aquaporins (Water Channels)IBA 11/2021 - 02/2015
3	Toll-Like Receptor 4IBA 12/2020 - 03/2015
3	OligodeoxyribonucleotidesIBA 01/2020 - 04/2010
3	Biological ProductsIBA 12/2019 - 11/2005
3	Caspase 3 (Caspase-3)IBA 07/2012 - 02/2009
3	Angiotensin IIIBA 01/2006 - 01/2003
2	Betulinic AcidIBA 10/2022 - 01/2019
2	AntioxidantsIBA 10/2022 - 01/2019
2	Analgesics (Analgesic Drugs)IBA 07/2022 - 11/2021
2	NF-kappa B (NF-kB)IBA 02/2022 - 07/2012
2	HMGB1 Protein (HMG1)IBA 01/2022 - 01/2020
2	ChemokinesIBA 01/2022 - 01/2021
2	6,7-dihydroxyflavoneIBA 10/2021 - 01/2021
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2021 - 09/2017
2	LigandsIBA 01/2020 - 03/2015
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020 - 01/2016
2	Transient Receptor Potential ChannelsIBA 01/2019 - 08/2007
2	Glial Fibrillary Acidic ProteinIBA 01/2019 - 10/2008
2	ElementsIBA 10/2018 - 04/2014
2	Nitric Oxide Synthase (NO Synthase)IBA 09/2017 - 01/2016
2	Riluzole FDA LinkGeneric 11/2015 - 01/2012
2	SodiumIBA 04/2014 - 01/2012
2	CalciumIBA 01/2013 - 08/2007
2	PotassiumIBA 01/2013 - 01/2007
2	fluoro-jade CIBA 07/2012 - 10/2011
2	AngiotensinsIBA 10/2003 - 05/2003
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2003 - 01/2003

Therapy/Procedure

19	Therapeutics 07/2022 - 12/2010
10	Decompressive Craniectomy 01/2022 - 05/2009
6	Decompression 01/2021 - 01/2013
4	Craniotomy 11/2021 - 12/2009
3	Drug Therapy (Chemotherapy) 07/2022 - 01/2016
3	Surgical Decompression 01/2019 - 09/2012
3	Cardiopulmonary Resuscitation (CPR) 01/2018 - 10/2011
2	Intravenous Administration 10/2022 - 01/2019
2	Minimally Invasive Surgical Procedures 09/2019 - 02/2016
2	Artificial Respiration (Mechanical Ventilation) 05/2015 - 12/2011